Autophagy-Enhanced Nanoplatforms Eliminate Intracellular Bacteria and Block Bacteria-Driven Epithelial-Mesenchymal Transition for Tumor Metastasis Inhibition - PubMed
3 hours ago
- #nanoplatform
- #EMT inhibition
- #autophagy
- The nanoplatform HSO-OMDs is developed to target tumor intracellular bacteria, which drive epithelial-mesenchymal transition (EMT) and metastasis.
- HSO-OMDs enhance autophagy in tumor cells by promoting autophagosome maturation, fusion with lysosomes, and lysosome acidification.
- By eliminating intracellular bacteria through enhanced autophagy, HSO-OMDs block EMT processes, inhibiting both primary tumor growth and metastasis.
- This approach addresses challenges like drug resistance and side effects associated with traditional antibacterial methods like antibiotics.