The cellular ecosystem of skeletal muscle regeneration: molecular mechanisms, pathological disorders, and potential therapeutic strategies - PubMed
2 days ago
- #cellular ecosystem
- #therapeutic strategies
- #skeletal muscle regeneration
- Skeletal muscle regeneration involves a complex cellular ecosystem including muscle stem cells, immune cells, stromal cells, vascular cells, neural cells, and the extracellular matrix.
- Research focuses on multi-level regulatory networks like Wnt/β-catenin, TGF-β, Hippo/YAP, and AMPK pathways, along with epigenetic regulation, metabolic reprogramming, and extracellular vesicle communication.
- Pathological conditions impair regeneration, leading to failed repair, fibrosis, fatty infiltration, and loss of muscle function.
- This review outlines advances in regeneration from the cellular ecosystem perspective, dissects failure mechanisms in pathology, evaluates intervention strategies, and provides future research insights.
- Aim is to integrate knowledge and offer a foundation for developing clinical treatments for skeletal muscle regenerative disorders.