Neuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesis - PubMed
3 hours ago
- #ubiquitination
- #astrocyte morphogenesis
- #Neuroligin-2
- Neuroligin-2 (NL2) is crucial for astrocyte morphogenesis, influencing synapse development.
- NL2's intracellular WW-binding motif is essential for astrocyte growth.
- Astrocytic NL2 interactions differ from neuronal NL2, showing cell-specific roles.
- Nedd4l ubiquitinates NL2, stabilizing it and promoting astrocyte morphogenesis.
- NLs have distinct, non-overlapping functions in controlling astrocyte development.