Durable but impaired humoral and cellular immune responses against monkeypox virus in people with HIV over 18 months - PubMed
3 hours ago
- #immune response
- #HIV
- #Monkeypox virus
- Monkeypox virus (MPXV) infection induces durable humoral and cellular immune responses lasting up to 18 months in both people with HIV (PWH) and people without HIV (PWoH).
- People with HIV show impaired MPXV-specific immune responses, including attenuated antibody levels, reduced poxvirus-specific memory T cell frequencies, and decreased polyfunctionality compared to PWoH.
- HIV infection compromises immune coordination, weakening the concordance between humoral and cellular responses and disrupting interactions between CD4+ and CD8+ T cell subsets.
- HIV-specific memory T cell responses remain stable in antiretroviral-treated PWH, regardless of prior MPXV coinfection.
- The study underscores MPXV as an AIDS-defining opportunistic infection and highlights immune dysregulation in PWH despite durable responses.