Decoding the association between platinum resistance and HPV status in cervical cancer using organoid models - PubMed
3 hours ago
- #Platinum Resistance
- #HPV
- #Cervical Cancer
- Platinum resistance in cervical cancer is linked to non-HPV16 high-risk HPV types, showing enhanced DNA repair and PI3K/AKT pathway activation.
- Organoid models accurately mimic cervical cancer tumors, serving as effective tools for studying drug resistance mechanisms.
- Inhibiting the PI3K/AKT pathway with BYL719 can improve platinum drug response in non-HPV16 high-risk HPV organoids.