Multicellular senescence impairs skeletal muscle recovery following disuse in aging - PubMed
2 hours ago
- #senescent cells
- #aging
- #muscle recovery
- Aged skeletal muscle shows reduced recovery capacity after disuse compared to young muscle.
- Impaired recovery in aging involves an accumulation of senescent cells within muscle, identified through markers like p21 and γH2AX.
- Single-cell analysis reveals senescent interstitial cells in vascular, stromal, and immune populations that exhibit a senescence-associated secretory phenotype (SASP).
- Senolytic treatment reduces senescent cells, improves macrophage dynamics, and restores muscle mass and function in aged mice after disuse.