PML as a neuroprotective guardian: Leveraging nuclear protein quality control to mitigate neurotoxicity of an ALS-associated NEK1 variant - PubMed
4 hours ago
- #PML
- #Protein Degradation
- #ALS
- PML nuclear bodies act as hubs for SUMO-primed ubiquitylation and degradation of misfolded proteins, offering neuroprotection.
- An ALS-associated NEK1 truncation mutant is recruited to PML nuclear bodies for potential SUMOylation and ubiquitylation.
- Loss of PML worsens ALS-like symptoms in mice, while induced PML expression delays disease onset, highlighting its therapeutic potential.