Atlas of human brain imaging-derived phenotypes and disease risk - PubMed
3 hours ago
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- Identified 1,500 significant associations between 505 brain imaging-derived phenotypes (IDPs) and 756 incident diseases across 15 organ systems using multimodal MRI and health records from 64,836 participants.
- Revealed brain alterations are linked not only to neurological but also to peripheral conditions like circulatory, digestive, and metabolic disorders, with white matter-related IDPs serving as a central hub in brain-body health networks.
- Prediction models combining IDPs with clinical covariates improved disease discrimination, and Mendelian randomization indicated potential causal roles of white matter-related IDPs in cerebrovascular disorders.
- Established an open-access atlas (www.brainphewas.com) to advance population-level understanding of brain-body associations and support neuroimaging's potential in cross-system disease risk assessment and therapy development.