Intraductal Papillary Squamous Neoplasm (IPSN) of the Pancreas: Histologic and Molecular Characterization of a Novel and Distinct Intraductal Cancer Precursor - PubMed
3 days ago
- #pancreatic cancer
- #squamous differentiation
- #intraductal neoplasms
- IPSN is a rare intraductal pancreatic tumor with distinctive squamous differentiation and is often associated with invasive carcinoma.
- Genomic analysis shows shared somatic alterations between IPSN and invasive components, indicating a common clonal origin.
- Common molecular features include KRAS mutations, CDKN2A inactivation, and alterations in SWI/SNF complex and KMT2D.
- FGFR1 and MYC amplifications were found in separate cases, and TGF-β pathway changes were restricted to invasive parts.
- Transcriptomic profiling reveals basal-like expression in IPSN and SCC, with PDAC sometimes shifting to classical subtype.
- The study identifies IPSN as a novel precursor to pancreatic cancer, challenging views on squamous epithelium in tumor initiation.