p53 regulates mitochondrial function and alpha-synuclein aggregation in Parkinson's disease - PubMed
3 hours ago
- #mitochondrial function
- #alpha-synuclein
- #p53
- Mitochondrial dysfunction and abnormal alpha-synuclein aggregation are central to Parkinson's disease pathology.
- Increased p53 expression correlates with mitochondrial impairment and alpha-synuclein accumulation in PD mouse models.
- Inhibition of p53 regulates mitochondrial function via mitophagy and dynamics, reducing oxidative stress and apoptosis.
- p53 interacts with alpha-synuclein to accelerate its liquid-liquid phase separation and fibril formation.
- p53 modulates mitochondrial pathways, promoting pathogenic alpha-synuclein aggregation and neurodegeneration.