Structural investigation of QatB and QatC proteins in QatABCD anti-phage defense - PubMed
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- #Prokaryotic immunity
- #Anti-phage defense
- #Protein structure
- QatABCD is a common anti-phage defense system in prokaryotes with four protein components.
- QatC resembles QueC, an enzyme in queuosine biosynthesis, and its structure was solved bound to an ATP analog.
- QatB and QatC form a stable heterodimer, and their complex structure was determined.
- Structural analysis suggests QatB might be a substrate for QatC, hinting at a regulatory role.
- QatA and QatD are predicted to act as an ATPase and nuclease, respectively, while QatB lacks clear sequence motifs.