Plant Kelch phosphatases are Ser/Thr phosphatases involved in cell cycle regulation - PubMed
3 hours ago
- #Cell cycle regulation
- #Brassinosteroid signaling
- #Kelch phosphatases
- Plant Kelch phosphatases, previously thought to be tyrosine phosphatases, are actually Ser/Thr phosphatases structurally similar to PP1.
- BSU1 rescues bri1 mutants and dephosphorylates Ser/Thr, not Tyr, substrates; its PP1-like tail is regulated by phosphorylation at Thr785 via CDK.
- Loss-of-function bsu1 mutants show normal BR responses but exhibit stomatal and fertility defects, indicating roles beyond BR signaling.
- Deletion of MpBSLM in Marchantia leads to undifferentiated cell masses and cell cycle overactivation, linking Kelch phosphatases to cell cycle regulation.