Hyperbaric oxygen therapy improves clinical symptoms and functional capacity and modulates thalamic connectivity in ME/CFS: a prospective cohort study - PubMed

3 hours ago

Hyperbaric oxygen therapy (HBOT) significantly improved physical functioning, fatigue, pain, and cognitive performance in patients with ME/CFS.
HBOT shifted abnormal thalamic connectivity patterns in ME/CFS patients towards those seen in healthy controls, with greater reductions in hyperconnectivity linked to better clinical response.
The study reports high adherence and tolerability to HBOT with no major adverse events, supporting its feasibility as a treatment for ME/CFS.
The findings suggest thalamic dysregulation plays a role in ME/CFS pathophysiology and may be modulated by HBOT, providing a rationale for further controlled trials.

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