Hyperglycemia- induced innate immune tolerance involves the metabolic and epigenetic rewiring in human alveolar macrophages - PubMed
3 hours ago
- #alveolar macrophages
- #immune tolerance
- #hyperglycemia
- Hyperglycemia induces a persistent immune-tolerant phenotype in human alveolar macrophages (AMs), reducing pro-inflammatory cytokines and impairing phagocytosis.
- Metabolic reprogramming in tolerant AMs involves decreased oxidative phosphorylation without compensatory glycolysis, plus lipid dysregulation (acylcarnitine accumulation and reduced membrane lipids).
- Epigenetic changes include increased chromatin accessibility and enhanced H3K4me3 modifications at autophagy and apoptosis-related gene regions, linked to transcriptional downregulation of inflammation genes.
- These findings suggest a mechanistic link between hyperglycemia and increased pulmonary infection susceptibility in diabetes, highlighting potential immunomodulatory targets.