Hypothalamic POMC neurons regulate intestinal glucose absorption via a gut-brain circuit - PubMed
4 hours ago
- #POMC neurons
- #glucose absorption
- #gut-brain axis
- POMC neuron PKA activation in the hypothalamus reduces intestinal glucose absorption via vagal signaling.
- Constitutive PKA activation in POMC neurons leads to improved glucose tolerance despite increased insulin resistance and obesity.
- The POMC PKA-vagal-gut SGLT1 axis could be a therapeutic target for diabetes, especially in insulin-resistant individuals.