Microplastic Exposure Aggravates Cardiomyopathy Under Hemodynamic Stress Through the Gut-Heart Axis - PubMed
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- #cardiomyopathy
- #microplastics
- #gut-heart axis
- BPF exposure is linked to cardiomyocyte hypertrophy, cardiac dysfunction, and intestinal barrier damage, dependent on gut microbiota.
- Microbial metabolism converts BPF to NAP via Sat1, disrupting the gut barrier and activating cardiac p53, leading to hypertrophy.
- Akkermansia muciniphila and tryptophol mitigate BPF-induced injuries by downregulating the Sat1-NAP axis, suggesting therapeutic potential.