SAHH Deficiency Decreases Stability of Atherosclerotic Plaque and Induces VSMC Phenotype Switching via Epigenetic Upregulation of KLF4 and OCT4 - PubMed
3 days ago
- #Epigenetic Regulation
- #SAHH Deficiency
- #Atherosclerosis
- SAHH deficiency reduces atherosclerotic plaque stability and triggers VSMC phenotype switching.
- The mechanism involves epigenetic upregulation of KLF4 and OCT4 through SAH accumulation.
- SAHH deletion inhibits DNMT3b, leading to KLF4 promoter hypomethylation and increased expression.
- OCT4 reactivation occurs via KLF4-dependent TET1-mediated promoter hydroxymethylation.
- AMPK inhibition by SAHH deficiency downregulates TET2-mediated KLF4 promoter hydroxymethylation.
- Lower SAHH activity and higher SAH levels correlate with unstable plaques in patients with cardiovascular disease.