Human Urine Stem Cells Alleviate Pulmonary Fibrosis via Inhibiting Macrophage-Myofibroblast Transition - PubMed
3 hours ago
- #macrophage transition
- #pulmonary fibrosis
- #stem cells
- Human urine stem cells (hUSCs) alleviate pulmonary fibrosis by inhibiting macrophage-myofibroblast transition (MMT), a key process in idiopathic pulmonary fibrosis (IPF).
- hUSCs reduce alveolar epithelial cell damage, decrease macrophage infiltration, and suppress MMT in a mouse model of bleomycin-induced pulmonary fibrosis.
- The protective effect is mediated through paracrine actions, with DKK1 secreted by hUSCs inhibiting the Wnt/β-catenin pathway to prevent MMT in macrophages.
- These findings suggest hUSCs as a potential therapeutic strategy for treating IPF.