Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity - PubMed
3 hours ago
- #microtubule acetylation
- #Septin 9
- #epithelial polarity
- Septin 9's polybasic (PB) domains coordinate centrosome positioning and microtubule acetylation to regulate apico-basal polarity in epithelial cells.
- Disruption of septin 9 or its PB domains leads to centrosome symmetry, impaired cilia formation, and polarity inversion, linked to increased HDAC6 expression.
- Inhibition of TGF-β signaling or HDAC6 with tubacin restores microtubule acetylation and rescues epithelial polarity, highlighting a septin 9/TGF-β/HDAC6 pathway.