Human retinal organoids functionally bridge a transected optic nerve in a rat model - PubMed
3 hours ago
- #Optic Nerve Repair
- #Retinal Organoids
- #Visual Restoration
- Human retinal organoids were transplanted into the transected optic nerve of adult rats.
- Partial visual function recovery was observed, including pupillary light reflex and visually guided behaviors, lasting at least 3 months.
- A structured host-graft coupling formed across the transection gap, supporting signal transmission.
- Chemogenetic inhibition of the graft led to attenuation of visual function, confirming its role.
- The study offers a proof of concept for repairing severe optic nerve injuries using organoid transplantation.