Joint association of frailty and social isolation with depressive symptoms among middle-aged and older Chinese adults: a nationwide cohort study - PubMed
3 hours ago
- #Frailty
- #Depressive Symptoms
- #Social Isolation
- Frailty (frailty index ≥ 25) and social isolation (score ≥ 3) independently increase incident depressive symptoms risk among Chinese adults aged ≥45.
- Co-occurrence of frailty and social isolation shows the highest risk for depressive symptoms (HR 1.86), suggesting additive interaction.
- Study included 7330 participants, identifying 2007 incident cases, with findings consistent across gender and comorbidities.
- No definitive multiplicative interaction was found, and additive interaction was suggestive but not statistically definitive.