Dual targeting of cutaneous inflammation and vasculopathy via STING-NF-κB blockade underlies the anti-psoriatic efficacy of Yinxie Granules - PubMed
4 hours ago
- #STING inhibitor
- #Psoriasis
- #Traditional Chinese Medicine
- Yinxie Granules (YXKL) reduce psoriasis symptoms by targeting inflammation and abnormal blood vessels.
- YXKL works by inhibiting the STING/NF-κB pathway, not affecting upstream regulators like TRAF6 or AMPK.
- Quercetin and kaempferol are the active components in YXKL that bind to STING and block its pathway.
- This dual action suppresses skin inflammation and angiogenesis while improving blood vessel integrity.
- The findings identify STING/NF-κB as a key target for psoriasis treatment and offer natural STING inhibitors.