Mutant KRAS-driven selective mRNA translation reveals mechanisms and therapeutic vulnerabilities in cancer - PubMed
2 hours ago
- #KRAS
- #mRNA translation
- #cancer mechanisms
- Mutant KRAS controls specific mRNA translation programs distinct from mTOR and EIF4E-EIF4A signaling.
- It selectively regulates mRNAs with short, weakly folded 5'UTRs and low folding energy consensus sequences.
- Ribosome accumulation occurs on these mRNAs, affecting proteins involved in the translation machinery.
- KRAS inhibition leads to acute remodeling of these translational programs, revealing therapeutic vulnerabilities.
- The study redefines understanding of oncogenic mRNA translation regulation, particularly in pancreatic cancer.