Advancing high-altitude medicine: a model for the future - PubMed
3 hours ago
- #high-altitude medicine
- #hypoxia research
- #multi-organ injury
- Rising global high-altitude exposure increases health burden of altitude-specific and related diseases, necessitating research and clinical solutions.
- Introduces Hypoxia Stress-induced Multi-organ Injury (HSMI) Spectrum as a unifying paradigm to overcome fragmented research in hypoxia-driven multi-organ pathophysiology.
- Highlights barriers: incomplete understanding of individual hypoxia susceptibility, reliance on subjective diagnostic tools, and gaps in translating basic research to clinical therapies.
- Proposes advancement strategy including integrated systems-based research using multi-omics and machine learning, deciphering hypoxia molecular pathways, developing objective diagnostic systems, and innovating precision therapeutics.
- HSMI model aims to strengthen scientific foundation, optimize prevention and treatment, and provide scalable framework for health challenges in extreme hypoxic environments worldwide.