Head-to-head comparison of fasting-insulin-based versus non-insulin-based insulin resistance surrogates for predicting all-cause and cardiovascular mortality in hypertensive adults across the glycemic
3 hours ago
- #hypertension
- #mortality
- #insulin resistance
- The study compared 10 insulin resistance (IR) surrogates for predicting all-cause and cardiovascular mortality in hypertensive adults across glycemic statuses.
- HOMA-IR was the only fasting-insulin-based index independently associated with all-cause mortality across normoglycemia, prediabetes, and diabetes.
- eGDR (estimated glucose disposal rate) showed the strongest associations with both all-cause and cardiovascular mortality, particularly in prediabetes and diabetes.
- TyG index predicted all-cause and cardiovascular mortality, with significant associations in diabetes.
- The findings suggest selecting IR indices based on glycemic phenotype and data availability for prognostic use in hypertensive adults.