Molecular Insights into Parkinson's Disease Progression: A Multi-omics Analysis of the Substantia Nigra Pars Compacta across Braak Stages - PubMed
3 days ago
- #Parkinson's Disease
- #Substantia Nigra
- #Multi-omics
- Multi-omics analysis reveals stage-specific molecular changes in the substantia nigra pars compacta across Braak stages of Parkinson's disease in a Korean cohort.
- Transcriptomic and proteomic data show upregulation of extracellular matrix and immune response pathways, with downregulation of microtubule organization and neuronal function genes.
- Key upregulated genes (e.g., PARP3, SERPINE1) are linked to α-synuclein aggregation, cell death, and autophagy inhibition, while downregulated genes (e.g., TXNIP, KIF25) correlate with neuronal loss and mitochondrial dysfunction.
- Advanced Braak stages exhibit disrupted mitochondrial processes and elevated phospholipid binding pathways, closely associated with disease progression.
- Proteomic findings highlight increased markers of neuroinflammation and mitochondrial impairment, such as SNCA, GPNMB, and LGALS3, with potential as biomarkers for disease severity.