Minute-scale control of ubiquitin-mediated degradation reveals dynamics of bacterial secreted effector-functions - PubMed
5 hours ago
- #bacterial effectors
- #host-pathogen interactions
- #ubiquitin-mediated degradation
- Developed AIDE platform for rapid degradation of bacterial effectors in host cells.
- AIDE enables minute-scale, spatiotemporal control over effector activity in infections.
- Applied to Chlamydia trachomatis to dissect roles of Cdu1 and IncA.
- Provides reversible degradation while preserving native expression and secretion.