Establishment and validation of a prognostic model for pancreatic cancer utilizing genes of tumor-associated neutrophils - PubMed
4 hours ago
- #pancreatic cancer
- #prognostic model
- #tumor-associated neutrophils
- Identified four tumor-associated neutrophil (TAN)-related genes (AIM2, PSCA, IL18BP, LIPE) closely linked to pancreatic cancer prognosis.
- Developed a prognostic model using these genes, achieving high AUC values (0.774, 0.841, 0.953) for predicting 1-, 2-, and 3-year survival rates.
- Analyzed immune infiltration, revealing high levels of resting dendritic cells, naive B cells, CD8 T cells, and follicular helper T cells in pancreatic cancer patients.
- Conducted drug sensitivity analysis, showing higher IC50 values for dactolisib, docetaxel, gemcitabine, and ulixertinib in high-risk pancreatic ductal adenocarcinoma groups.
- Validated gene expression via online databases (HPA, TISCH) and experimental methods (IHC, qPCR) using clinical patient samples.