A Consensus Clustering Approach to Amyotrophic Lateral Sclerosis Phenotyping - PubMed
2 hours ago
- #consensus clustering
- #ALS phenotyping
- #motoneuron diseases
- The paper proposes a data-driven consensus clustering method for characterizing Amyotrophic Lateral Sclerosis (ALS) phenotypes using clinical data.
- The approach identifies stable clusters across multiple random data sub-samples to align patient groups and features with clinical knowledge and phenotypes.
- Results indicate consistent profiles for bulbar onset ALS patients, driven by onset characteristics, while spinal onset ALS patients show greater within-phenotype heterogeneity.