Regenerative macrophages enhance stem cell-derived β cell function and engraftment - PubMed
2 hours ago
- #stem cells
- #regenerative medicine
- #type 1 diabetes
- Stem cell-derived β cells (SC-β cells) offer promise for treating type 1 diabetes.
- Macrophages are essential for islet development and enhance SC-β cell differentiation.
- Regenerative macrophages (SC-MReg) improve maturity, glucose-stimulated insulin secretion, and metabolic activity in SC-β cells.
- Coaggregating SC-β cells with SC-MRegs accelerates glycemic normalization in diabetic mice.
- Adding macrophages during SC-β differentiation advances functional maturation for regenerative therapy.