Nitroimidazole - albendazole combination therapy, quinacrine use, and risk factors in nitroimidazole-refractory giardiasis: a prospective multicentre observational study - PubMed
4 hours ago
- #quinacrine efficacy
- #giardiasis treatment
- #nitroimidazole resistance
- Nitroimidazole-refractory giardiasis is an increasing problem, prompting the study of second and third-line treatments.
- A prospective multicentre observational study of 120 patients (plus 20 from a Swiss cohort) assessed treatment efficacy and risk factors.
- Treatment ladder included a repeated nitroimidazole course (24% cure rate), nitroimidazole-albendazole combination (76% cure rate), and quinacrine (100% cure rate).
- Assemblage typing showed Assemblage B was common in travelers from India and Africa, but only India acquisition and more recent diagnosis year were significant risk factors for nitroimidazole failure.
- The study concludes that nitroimidazole-albendazole combination and quinacrine are effective in refractory cases, with India-acquired infections highly associated with treatment failure.