Telomere heterochromatin-mediated compartmentalization: Where ALT begins - PubMed
3 hours ago
- #telomere
- #ALT
- #heterochromatin
- Alternative lengthening of telomeres (ALT) is a recombination-mediated telomere maintenance mechanism.
- The core ALT machinery is defined, but initiating events are unresolved.
- Telomeric heterochromatin enrichment drives nuclear compartmentalization, promyelocytic leukemia body nucleation, and telomere clustering.
- This establishes a chromatin-defined environment permissive for recombination, indicating where ALT begins.