Lactylation-related prognostic signature characterized in pancreatic ductal adenocarcinoma through public scRNA-seq dataset and machine learning algorithms: the TOP2A-H3K18la-NQO1 axis orchestrates ma
3 hours ago
- #lactylation
- #prognostic model
- #pancreatic ductal adenocarcinoma
- A lactylation-related prognostic risk score model was developed for pancreatic ductal adenocarcinoma (PDAC) using single-cell RNA sequencing data and machine learning.
- The lactate-TOP2A-H3K18la-NQO1 signaling axis forms a positive feedback loop that accelerates malignant progression in PDAC.
- The study links risk scores to clinical features, immune profiles, mutation burden, and biological functions, validated through in vitro experiments and xenograft models.