A plasma protein signature for cerebral amyloid angiopathy - PubMed
3 hours ago
- #Cerebral Amyloid Angiopathy
- #Blood Biomarkers
- #Alzheimer's Disease
- Cerebral amyloid angiopathy (CAA) involves amyloid-β deposition in brain blood vessels, increasing risk of hemorrhages and cognitive decline.
- Over 90% of Alzheimer's disease (AD) cases show some CAA, and it is a risk factor for amyloid-related imaging abnormalities (ARIA) with anti-amyloid treatments.
- The study used NULISA™ to explore plasma biomarkers in cohorts from Banner Sun Health and UC Irvine, analyzing samples taken close to death.
- A multi-biomarker model including CRP, IL4, CCL11, NPY, PDLIM5, and demographics achieved an AUC of 0.90 for identifying neuropathologically confirmed CAA.
- Validation showed the plasma signature outperformed basic demographics, suggesting potential for antemortem CAA prediction in clinical settings.