Eosinophilic Granulomatosis with Polyangiitis that Manifested after Administration of Benralizumab in a Patient with Refractory Recurrent Bronchial Asthma - PubMed
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- #Benralizumab
- #Refractory Asthma
- #Eosinophilic Granulomatosis with Polyangiitis
- A 73-year-old woman with a history of bronchial asthma treated with glucocorticoids since age 21 developed a rash and peripheral neuropathy.
- Benralizumab was started six years before, leading to glucocorticoid discontinuation one year later and 5 years of asthma remission.
- Upon admission, tests showed mild urinary abnormalities, positive myeloperoxidase-specific antineutrophil cytoplasmic antibody, and eosinophilia, with renal biopsy indicating mild necrotizing vasculitis with eosinophilia.
- Eosinophilic Granulomatosis with Polyangiitis (EGPA) was diagnosed post-benralizumab, and treatment was switched to glucocorticoids and mepolizumab.
- After discontinuing benralizumab and starting new treatment, both EGPA and asthma remained in remission.