Myostatin Signaling in Skeletal Muscle: Implications for Athletic Performance - PubMed
4 hours ago
- #myostatin
- #sports genetics
- #muscle hypertrophy
- Myostatin is a negative regulator of skeletal muscle growth, influencing satellite cell activity and protein synthesis through Smad and non-Smad pathways.
- Reduced myostatin activity enhances muscle regeneration via the IGF-1/Akt/mTOR pathway and is linked to improved metabolic function and athletic performance.
- Genetic variations in MSTN and its receptors, such as ACVR2A/B, contribute to differences in muscle strength, hypertrophy, and endurance among individuals.
- Specific polymorphisms like rs1805086 and rs11333758 are associated with variations in muscle morphology and athletic capabilities.
- The review covers myogenesis, MSTN signaling, genetic factors, endocrine interactions, and therapeutic strategies, highlighting future research directions in sports genomics.