[Metformin for the Prevention of Hyperemesis Gravidarum: From a GDF15-Based Rationale to Early Clinical Evidence] - PubMed
3 hours ago
- #Metformin
- #Hyperemesis Gravidarum
- #GDF15
- GDF15 is central to hyperemesis gravidarum (HG) pathophysiology; low pre-gestational levels may cause hypersensitivity when levels rise in the first trimester.
- Metformin may prevent HG recurrence by increasing GDF15 pre-conception, based on observational data suggesting reduced risk, though evidence is limited by low statistical power.
- Early clinical evidence shows a trend toward lower HG risk with preconception metformin, but no randomized trials confirm efficacy, requiring further studies before recommendations.