The Association Between MOG-IgG Positivity and mRNA SARS-CoV-2 Vaccination in Denmark: A Self-Controlled Case Series Study - PubMed
3 hours ago
- #MOGAD
- #vaccine safety
- #COVID-19 vaccination
- Study investigated link between MOG-IgG positivity (proxy for MOGAD) and mRNA SARS-CoV-2 vaccination in Denmark using a self-controlled case series design.
- Among 5.9 million eligible individuals, 111 incident MOG-IgG positive events were identified, with 28 occurring in children.
- No association found between mRNA vaccination and MOG-IgG positivity in adults, but an increased risk was observed in children under 18 (IRR = 8.07, 95% CI: 3.07-21.21).
- If causal, estimated 4.38 excess MOG-IgG positive events per 1 million vaccinated children in Denmark.
- Risk of MOGAD attributable to vaccination in children is very low, and further studies are needed to confirm findings.