Inhibition of Pax6 sumoylation suppresses the tumorigenicity of pancreatic cancer cells - PubMed
3 hours ago
- #sumoylation
- #Pax6
- #pancreatic cancer
- Pax6 is a transcription factor regulated by sumoylation at Lys-91 and Lys-110 residues.
- Inhibition of Pax6 sumoylation with ML-792 suppresses tumor growth in pancreatic cancer cells and developed tumors.
- Mutation of Pax6 at K91/110R also inhibits tumor development, and similar changes occur in knock-in mice.
- CXXC4 is identified as a major downstream target directly regulated by Pax6.
- Silencing CXXC4 reduces tumorigenicity, mimicking the effect of Pax6 sumoylation inhibition.