Immune-mediated multisystem injury associated with monoclonal gammopathy of clinical significance: a case report - PubMed
3 hours ago
- #Monoclonal Gammopathy
- #Immune-Mediated Injury
- #Case Report
- MGCS involves pathogenic monoclonal immunoglobulins causing organ injury independent of tumor burden.
- A 52-year-old man presented with cutaneous xanthomatosis, inflammatory myopathy, cryoglobulinemia, and possible cardiac involvement.
- Symptoms included polymyalgia, leukopenia, and skin plaques, with immune abnormalities predating monoclonal protein detection.
- Lab findings showed IgG-λ monoclonal gammopathy, type I cryoglobulinemia, complement consumption, and autoantibodies.
- Bone marrow had only 1.4% λ-restricted clonal plasma cells, indicating low tumor burden.
- Treatment with bortezomib-cyclophosphamide-dexamethasone led to significant clinical improvement.
- Case highlights immune-mediated injury can precede detectable clonal expansion in MGCS.