ALKBH4 confers ferroptosis resistance and drives tumorigenesis via dysregulation of GPX4 in breast cancer cells - PubMed
2 hours ago
- #ALKBH4
- #Ferroptosis
- #Breast Cancer
- ALKBH4 is overexpressed in breast cancer and associated with poor clinical outcomes.
- Knocking down ALKBH4 inhibits breast cancer cell proliferation, migration, and invasion while promoting apoptosis.
- ALKBH4 knockdown triggers ferroptosis, indicated by increased MDA, Fe2+, ROS, and depleted GSH levels.
- ALKBH4 maintains GPX4 protein levels in a demethylase activity-dependent manner to confer ferroptosis resistance.
- Overexpression of GPX4 reverses ferroptosis and growth defects caused by ALKBH4 loss, enhancing anti-tumor effects.