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Cathy Tie's mission to genetically modify babies

7 hours ago
  • #Gene Editing Ethics
  • #Biotech Entrepreneurship
  • #Reproductive Technology
  • Cathy Tie, a Canadian serial entrepreneur, celebrated her 30th birthday with a piano performance at Carnegie Hall, hiring the venue for a party attended mostly by strangers.
  • She has launched multiple biotech startups, moved frequently between cities, and was briefly married to He Jiankui, the scientist imprisoned for creating the world's first gene-edited babies.
  • Tie's current venture, Origin Genomics, aims to edit embryos to prevent severe genetic diseases like cystic fibrosis, advocating for open, regulated research despite germline editing being banned in many countries.
  • She argues that gene editing is safer now due to technological advances, with careful sequencing to avoid unintended changes, and claims embryo editing is morally preferable to discarding affected embryos.
  • Tie highlights the geopolitical and competitive aspects of biotech, noting investments by figures like Sam Altman and referencing China's advancements, while drawing parallels to the Manhattan Project.
  • Despite her commitment to transparency, Tie keeps many details secret, such as her team, investors, and lab location, and has faced setbacks, including a previous startup shutdown due to co-founder issues.
  • She defends the high cost of future treatments, suggesting initial expenses are typical for new technologies, and emphasizes public engagement to shape ethical norms.
  • Tie's past includes biohacking pets for designer traits, but she now focuses on human health, though she avoids discussing her relationship with He Jiankui and the ethical implications of his work.
  • She believes regulations should define 'severe' diseases, relying on patient advocacy, and sees gene editing as inevitable, comparing concerns to historical debates over IVF.
  • In public debates, Tie engages with bioethicists, aiming to shift perceptions and gain acceptance, confident that demand and investment will drive legal changes in the field.