B7-H3 CAR T cells eradicate intrahepatic cholangiocarcinoma and induce durable response - PubMed
3 hours ago
- #cholangiocarcinoma
- #immunotherapy
- #cancer research
- B7-H3 is overexpressed in intrahepatic cholangiocarcinoma (ICC), making it a promising target for immunotherapy.
- Researchers developed B7-H3-targeted CAR T cells with a suicide safety switch (iCas9) for enhanced control.
- In vitro tests showed potent anti-tumor activity against human ICC cell lines and patient-derived models.
- In vivo studies in mice demonstrated complete and durable eradication of ICC tumors after a single systemic CAR T cell dose.
- Locoregional delivery methods (splenic or intra-tumoral injection) were as effective as systemic administration.
- The findings support advancing B7-H3 CAR T cell therapy into clinical trials for advanced ICC.