A conserved mechanism for stabilization of viral innate immune antagonists via interaction with Elongin BC - PubMed
2 hours ago
- #Elongin BC interaction
- #viral innate immune evasion
- #interferon signaling inhibition
- Viral proteins like rotavirus NSP1 inhibit IRF3 to block interferon signaling.
- NSP1 interacts with Elongin BC via a BC box motif for proteasomal degradation of IRF3.
- Disruption of Elongin B (TCEB2) prevents IRF3 degradation by NSP1.
- Rotaviruses with mutated NSP1 BC boxes fail to degrade IRF3, enhancing interferon responses and attenuation.
- Elongin BC stabilizes NSP1 and other viral antagonists (e.g., pestiviral N proteases, adenovirus E4orf6).
- Elongin BC acts as a stabilizing factor for viral immune antagonists, beyond being an adaptor for degradation.