S100A10-ANXA2 tetramer inhibition hampers hepatic stellate cell activation in human MASLD organoids - PubMed
4 hours ago
- #fibrosis
- #MASLD
- #stellate cells
- S100A10-ANXA2 tetramer inhibition reduces hepatic stellate cell activation and fibrosis in MASLD models.
- The inhibitor A2ti-1 lowers α-SMA protein levels, collagen deposition, and profibrotic gene expression without affecting steatosis.
- Mechanistically, A2ti-1 inhibits activation via reduced STAT3 phosphorylation, independent of SMAD signaling.