Identification of drug-related cardiovascular risks: A comprehensive analysis using the FAERS database (2004-2024) - PubMed
3 hours ago
- #FAERS database
- #cardiovascular risk
- #drug safety
- Study analyzes drug adverse events from the FAERS database (2004-2024) to identify high-risk medications associated with cardiovascular disease (CVD).
- Rofecoxib, phenylpropanolamine, and rosiglitazone showed strong CVD associations, leading to withdrawal or restrictions; potential new risks were flagged for drugs like paricalcitol and busulfan.
- Subgroup analysis indicates gender and age differences in CVD risk, such as testosterone drugs in elderly males and alendronic acid in females, possibly due to mixed indications.
- Research confirms known risks like doxorubicin cardiotoxicity in children and suggests further investigation is needed to establish causality for new signals.
- Findings provide evidence for clinical medication safety and generate hypotheses on drug-related cardiovascular risks, but require validation through additional studies.