Ursodeoxycholic acid inhibits feline infectious peritonitis virus infection through activating JAK-STAT signaling pathway-induced type I interferon - PubMed
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- #Antiviral Mechanism
- #Feline Virology
- #Drug Development
- Ursodeoxycholic acid (UDCA) inhibits feline infectious peritonitis virus (FIPV) infection.
- UDCA activates the JAK-STAT signaling pathway by promoting interferon-β secretion.
- This activation upregulates interferon-stimulated genes, enhancing antiviral protein expression.
- UDCA also directly disrupts the FIPV envelope, causing viral structure disintegration.
- The study developed a CRFK-PHBLV-N cell line for efficient FIPV culture in vitro.
- Findings provide a new drug candidate and theoretical basis for anti-FIPV strategies targeting host pathways.