The role of acrylamide exposure in prostate cancer progression: An integrated analysis based on network toxicology and experimental validation - PubMed
3 hours ago
- #MAPK Pathway
- #Acrylamide
- #Prostate Cancer
- Acrylamide (AA), an environmental and food pollutant, was studied for its role in prostate cancer progression.
- 165 differentially expressed AA-related genes (DEARGs) were identified, enriched in PI3K-Akt and cAMP signaling pathways.
- A prognostic model with six DEARGs (CYP11A1, TUBB3, ALB, ESPL1, FOXN4, ISYNA1) predicted biochemical recurrence-free survival in prostate cancer patients.
- Glycidamide (GA), a metabolite of AA, upregulated most target genes and enhanced prostate cancer cell proliferation, migration, invasion, and tumor growth.
- The MAPK pathway was identified as a key mechanism through which GA promotes prostate cancer progression.