β-Elemene Rescues Radiation-Induced Enteritis by Orchestrating a Host-Microbiome Circuit That Fuels Epigenetic DNA Repair - PubMed
2 hours ago
- #radiation-induced enteritis
- #β-elemene
- #lactylation
- β-elemene protects against radiation-induced enteritis by coordinating host and gut microbiome responses.
- It restores lactate transporter activity in intestinal cells and enriches Lactobacillus gasseri, increasing lactate levels.
- Lactate promotes DNA repair through a lactylation-driven epigenetic pathway involving RBBP4 and EP300.
- The study proposes a 'prime-and-fuel' therapeutic strategy integrating drug-microbe-metabolite-epigenome interactions.