Autophagy Inhibition Reprograms the Tumor Microenvironment of Pancreatic Cancer to Promote Macrophage Phagocytosis of Tumor Cells - PubMed
3 hours ago
- #pancreatic cancer
- #macrophage phagocytosis
- #autophagy inhibition
- Autophagy inhibition in pancreatic ductal adenocarcinoma (PDAC) recruits macrophages through the CXCL1/2-CXCR2 axis.
- Loss of autophagy reduces expression of the 'don't eat me' ligand CD47 on tumor cells, making them more susceptible to macrophage phagocytosis.
- CD8+ T cells are essential for the anti-tumor response but work indirectly by stimulating macrophage phagocytosis rather than through direct cytotoxicity.
- The study supports autophagy inhibition as a therapeutic strategy in pancreatic cancer by reprogramming the tumor microenvironment to enhance immune-mediated tumor cell killing.